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子宮內(nèi)膜間質(zhì)肉瘤特異性標(biāo)志物及臨床病理分析
（作者未知） 2010/8/30
[摘要] 目的:探討子宮內(nèi)膜間質(zhì)肉瘤(ESS)中特異性標(biāo)志物雌激素受體(ER)、孕激素受體(PR)、表皮生長因子受體(EGFR)、結(jié)蛋白(desmin)、CD10、CD44的表達(dá),并分析ESS的臨床病理特征。方法:收集2000～2009年本院收治的32例ESS患者,通過免疫組化染色(SP法)檢測ER、PR、EGFR、desmin、CD10和CD44在ESS中的表達(dá),并在鏡下觀察其病理學(xué)特征。另取30例子宮平滑肌瘤作為對照。結(jié)果:ESS多為單發(fā),腫瘤類似增生期子宮內(nèi)膜間質(zhì)細(xì)胞,瘤細(xì)胞呈圓形、卵圓形、梭形,排列密集。EGFR在ESS和子宮平滑肌瘤中的陽性表達(dá)率差異無統(tǒng)計(jì)學(xué)意義(P﹥0.05),ER、PR、desmin、CD10、CD44在ESS和子宮平滑肌瘤中的陽性表達(dá)率差異有統(tǒng)計(jì)學(xué)意義(P﹤0.05或P﹤0.01)。結(jié)論:診斷ESS時(shí)應(yīng)結(jié)合其臨床病理特征,CD10可作為診斷ESS的特異指標(biāo),CD44可輔助診斷ESS。
[關(guān)鍵詞] 子宮內(nèi)膜間質(zhì)肉瘤;特異性標(biāo)志物;病理分析
[Abstract] Objective: To investigate the expressions of specific markers estrogen receptor (ER), progesterone receptor (PR), epidermal growth factor receptor (EGFR), desmin, CD10 and CD44 in endometrial stromal scarcoma (ESS), and analyze the clinical pathologic features of ESS. Methods: A total of 32 cases of patients with ESS from 2000 to 2009 in our hospital were selected, and the expressions of ER, PR, EGFR, desmin, CD10 and CD44 in ESS were detected by using immunohistochemical SP assay, and its pathologic features were observed under microscope. 30 cases of leiomyosarcoma uteri were selected as controls. Results: Most ESS were solitary tumors, it was similar to endometrial stroma cells of proliferative phase, cells were round, oval and fusiform, the arrangement was intensive. The positive expression rate of EGFR had no significant difference between ESS and leiomyosarcoma uteri (P﹥0.05), the positive expression rates of ER, PR, desmin, CD10 and CD44 had significant difference between ESS and leiomyosarcoma uteri (P﹤0.05 or P﹤0.01). Conclusion: The clinical pathologic features should be considered when diagnosing ESS, CD10 can serve as the sensitive marker in the diagnosis of ESS, and CD44 can serve as the auxiliary marker in the diagnosis of ESS.
[Key words] Endometrial stromal scarcoma; Specific marker; Pathologic analysis
子宮內(nèi)膜間質(zhì)肉瘤(endometrial stromal sarcoma,ESS)是來源于子宮內(nèi)膜間質(zhì)細(xì)胞的一種罕見的婦科惡性腫瘤,占子宮肉瘤的7%～15%,好發(fā)于絕經(jīng)前后婦女。臨床上主要表現(xiàn)為不規(guī)則陰道流血、絕經(jīng)后陰道流血、子宮增大、腹痛、腹部包塊等[1-3]。筆者收集2000～2009年本院收治的32例ESS患者,對其特異性標(biāo)志物的表達(dá)及臨床病理（未完，下一頁）
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