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不同基因型新城疫病毒對(duì)美國白羽王鴿的致病性研究
（作者未知） 2012/2/2
摘要：為比較鴿源Ⅵb 亞型新城疫病毒(NDV)與其它不同基因型NDV 對(duì)鴿的致病性差異，本研究選取
JS-7-05-Ch (基因Ⅲ型)、WX-10-07-Pi (基因Ⅵb 型)、JS-5-05-Go (基因Ⅶd 型)和F48E8 (基因Ⅸ型) 4 個(gè)病毒株，分別人工感染2 月齡實(shí)驗(yàn)鴿。接種后，觀察實(shí)驗(yàn)鴿臨床癥狀、病理剖解變化、同時(shí)檢測(cè)HI 抗體水平變化、喉氣管和泄殖腔排毒以及病毒在組織分布情況。4 株NDV 均能導(dǎo)致接種鴿的發(fā)病，但死亡率分別為0、0、100 %、50 %。WX-10-07-Pi 接種組鴿泄殖腔排毒時(shí)間最長、而且病毒檢出率比其它組高。另外，在接種組鴿的多種組織器官中均可檢測(cè)出病毒。實(shí)驗(yàn)結(jié)果表明，不同基因型NDV 對(duì)鴿均有致病性，但致病力強(qiáng)弱與NDV 毒株特性有關(guān)；基因Ⅵb 型NDV 在鴿體內(nèi)可長期的帶毒與排毒，與其它基因型NDV 相比更易在鴿群中傳播。
關(guān)鍵詞：新城疫病毒；鴿；致病性；排毒
Abstract: To evaluate the pathogenicity of Newcastle disease virus (NDV) strains of different genotypes in pigeons,JS-7-05-Ch, WX-10-07-Pi, JS-5-05-Go and F48E8 NDV strains that belonged to genotype Ⅲ , Ⅵ , Ⅶ and Ⅸ , respectively, werechosen to artificially infect two-month-old pigeons. Clinical symptoms and pathological changes of pigeons were observed, and humoral antibody response, virus shedding and virus distribution in tissues were examined. The results showed that NDVs could cause 100 % morbidity in pigeons and the mortality of pigeons infected with genotype Ⅲ-, Ⅵ-, Ⅶ- and Ⅸ-infected groups was 0, 0,100 % and 50 %, respectively. Pigeons infected with WX-10-07-Pi experienced longer time in virus shedding and showed higherratio of virus isolation when compared with other pigeons, which indicated that the Ⅵb NDVs might have genetic advantages over
other genotypes in NDV outbreaks in pigeons.
Key words : Newcastle disease virus; pigeons; pathogenicity; virus shedding
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