|
宮腔鏡檢查結(jié)合P21WAF1、CyclinE表達(dá)早期診斷子宮內(nèi)膜癌的臨床研究
孔玉玲，原繼榮，李本英（哈爾濱醫(yī)科大學(xué)附屬第二醫(yī)院黑龍江哈爾濱150086） 2010/6/2
摘要：目的探討宮腔鏡及抑癌基因P21WAF1、細(xì)胞周期素E(CyclinE)表達(dá)對子宮內(nèi)膜癌的早期診斷的意義。方法宮腔鏡檢查682例患者，選取其中10例正常子宮內(nèi)膜，14例子宮內(nèi)膜不典型增生，27例子宮內(nèi)膜癌應(yīng)用免疫組織化學(xué)法檢測P21WAF1及CyclinE基因表達(dá)。結(jié)果宮腔鏡及病理檢查確診27例子宮內(nèi)膜癌(3.96%)；三種組織比較，P21陽性表達(dá)率逐漸降低，CyclinE陽性表達(dá)率逐漸增高，差異均有顯著性。結(jié)論宮腔鏡定位活檢結(jié)合P21WAF1及CyclinE表達(dá)可早期診斷子宮內(nèi)膜癌。
關(guān)鍵詞：宮腔鏡；子宮內(nèi)膜癌；P21WAF1；CyclinE
StudyonsignificanceofhysteroscopyandexpressionofP21WAF1,CyclinEinearlydiagnosisofendometrialcarcinoma.KONGYu-ling，YUANJi-rong,LIBen-ying.(DepartmentOfObstetricsandGynecology,TheSecondHospitalAffiliatedHarbinMedicalUniversity,Harbin,150086)
Abstract:Objective:TodetectthesignigicanceofhysteroscopyandexpressionofP21WAF1,CyclinEinearlydiagnosisofendometrialcarcinoma.Methods:Thediagnostictechniqueofhysteroscopywasusedtoexanine682patients.ImmunohistochemistrytestwasusedtoexaminetheexpressionofP21WAF1andCyclinEin10caseofnormalendometrium,14caseofuterusatypicalhyperplasiaendometriumand27caseofendometrialcarcinoma.Results:27endometrialcarcinomapatients(3.96%)weredigonsiseddefinitelybythecombineduseofhysteroscopyanddirectedbiopsies.Inthethreeendometriumtissues,thepositiveexpressionrateofP21WAF1islowersignificantly;thepositiveexpressionrateofCyclinEishighersignificantly.Conclusion:Thecheckofhysteroscopy,colposcopyandtheexpressionofP21WAF1andCyclinEplayandimportantroleinearlydiagnosisofendometrialcarcinoma.
Keywords:Endometrialcarcinoma;Hysteroscopy;P21WAF1;CyclinE
......
附件下載：點(diǎn)擊論文下載
|